Cell enrichment and separation technique using active hydrogel membranes

Abstract Detection and isolation of target cells from heterogeneous mixtures are highly demanded in medicine, tissue engineering, cell biology. Likewise requested measuring techniques for significant biomarkers indicating changes cellular phenotype like size distribution deformability blood cells. A forward‐looking label‐free enrichment concept based on a membrane system made out stimulus‐responsive hydrogel is strived for. Therefore, order to obtain the necessary insight into deformable objects transported within microfiltration system, behavior (i) flow, (ii) membrane, (iii) cells, as well their interactions, has be understood. In present research both, experimental numerical investigations performed.